Risk factors for mortality of patients with COVID-19 in Morocco: A retrospective cohort study

Nowadays, COVID-19 remains one of the major public health issues of our time. More than 70 million cases and 1.6 million deaths have been reported worldwide. The epidemiological, clinical and biological characteristics of patients who died with severe COVID-19 and the risk factors for mortality have not been well described. The main objective of our study is to describe the epidemiological, clinical and some biological characteristics of nine COVID-19 patients deceased, as well as the risk factors for morbi-mortality. In this retrospective cohort study, we included nine adult patients with laboratory confirmed COVID-19, who had died. Demographic, clinical and biological data were collected and collated from the patients' medical records. The results of our study, of patients aged 46 to 78 years, showed a male predominance of 67%. All cases had a comorbidity, with hypertension and diabetes being the most common [44.45%]. Evaluation of the ratio of diseased to healthy lung shows that the majority of deaths (77.78%) showed a degree of severe lung involvement (50%-75%). The results also show that these severe cases manifest an intense elevation of certain biological markers of inflammation and blood clotting processes, including C-Reactive protein (CRP) and Ddimers. Lymphopenia is manifested in 77.78% of cases. The Results of these experiments showed the potential risk factors of older age, C reactive protein, d-dimer and lymphopenia. These factors could help to identify patients with poor prognosis earlier.

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