African Journal of Respiratory Medicine received 855 citations as per google scholar report
Objective: The association of smoking with glycemic level may suggest long term effects that may lead to airways ob- struction. We aimed to study the effect of glycemic state on lung functions in asymptomatic current cigarettes smokers.
Methods: This observational cross sectional study was con- ducted on 100 asymptomatic current cigarette smokers. Data regarding age, sex, smoking history including age of onset, smoking index and smoking duration were taken. Spirometric-indices (VC%, FVC%, FEV1%, FEV1/FVC ratio, FEF25-75%), Serum fasting plasma glucose mg/dl (FPG) and glycated hemoglobin% (HbA1C%) were measured.
Results: Spirometric-indices were significantly lower in smokers with pre DM and DM compared to those with no DM (p <0.05). Frequencies of large and small airways ob- struction were significantly higher in smokers with pre DM and DM compared to those with no DM (p <0.05). Multi- variate linear regression analysis revealed that HbAIC and FBG mg/dl values were predictive factors for decreased FEV1/FVC (p=0.001, B=1.202), (p=0.03, B=-0.068) respectively and decreased FEF 25-75% (p<0.001, B=-2.196), (p<0.001, B=0.158) respectively.
Conclusion: Lower spirometric indices in smokers with DM and pre-DM compared to smokers with no DM support the relationship between COPD and DM. The increased HbA1C and FBS level among smokers are predictors of both large and small airways obstruction (p <0.05).
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